文献类型：期刊文献

英文题名：Facile and practical hydrodehalogenations of organic halides enabled by calcium hydride and palladium chloride

作者：Gui, Jingjing[1,2];Cai, Xin[1,2];Chen, Lingyun[1,2];Zhou, Yuxin[1,2];Zhu, Wenjing[1,2];Jiang, Yuanrui[1,2];Hu, Min[1,2];Chen, Xiaobei[3,4];Hu, Yanwei[1,2];Zhang, Shilei[1,2]

机构：[1]Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China;[2]Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2021

卷号：8

期号：17

起止页码：4685

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20213510835734);WOS:【SCI-EXPANDED(收录号:WOS:000670328200001)，CCR-EXPANDED(收录号:WOS:000670328200001)】；

基金：This work was supported by the National Natural Science Foundation of China (22071053 and 21202112), PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions) and East China University of Science and Technology, the '111' Project.

语种：英文

外文关键词：Aromatic compounds - Aromatization - Chlorine compounds - Hydrides - Calcium compounds

摘要：Herein, a convenient hydrodehalogenation method was described by employing less-explored calcium hydride as the reductant. A wide range of organic halides such as aromatic bromides, aromatic chlorides, aromatic triflates, aliphatic bromides and aliphatic chlorides were efficiently and selectively reduced to obtain the corresponding hydrocarbons. More importantly, monodehalogenation of trihalomethyl compounds in THF could provide various useful dihalomethyl products.