文献类型：期刊文献

英文题名：Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes

作者：Niu, Dechao[1];Li, Yongsheng[1];Ma, Zhi[3];Diao, Hua[4];Gu, Jinlou[1];Chen, Hangrong[2];Zhao, Wenru[1];Ruan, Meiling[2];Zhang, Yonglian[5];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China;[4]Shanghai Inst Planned Parenthood Res, Shanghai 200032, Peoples R China;[5]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China

年份：2010

卷号：20

期号：5

起止页码：773

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20101012751674);WOS:【SCI-EXPANDED(收录号:WOS:000275937000011)】；

基金：This work was financially supported by the National Hi-Tech Project of China (Grant No.2007AA03Z317), the Shanghai Natural Science Foundation (Grant No.07ZR14028), the National Natural Science Foundation of China (Grant No.20633090), and the Shanghai Pujiang Program (Grant No. 09PJ1403000). The authors thank Dr. Liangping Zhou of the Shanghai Cancer Hospital, Fudan University for the MRI measurements and fruitful discussions. Supporting Information is available online from Wiley InterScience or from the author.

语种：英文

外文关键词：Solutions - Fluorescence - Iron alloys - Particle size - Self assembly - Cytotoxicity - Magnetic resonance imaging - Magnetite nanoparticles - Nanomagnetics - Silica - Superparamagnetism - Nanospheres - Sol-gel process - Cell culture

摘要：Novel, thiol-functionalized, and superparamagnetic, silica composite nanospheres (SH-SSCNs) with diameters smaller than 100 nm are successfully fabricated through the self-assembly of Fe(3)O(4) nanoparticles and polystyrene(100)-block-poly(acrylic acid)(16) and a subsequent sol-gel process The size and. magnetic properties of the SH-SSCNs can be easily tuned by simply varying the initial concentrations of the magnetite nanoparticles in the oil phase. By incorporating fluorescent dye molecules into the silica network the composite, nanospheres can be further fluorescent-functionalized. The toxicity of the SH-SSCNs is evaluated by choosing three typical cell lines (HUVEC RAW264.7 and A549) as model cells, and no toxic effects are observed. It is also demonstrated that SH-SSCNs can be used as a new class of magnetic resonance imaging (MRI) probes, having a remarkably high spin-spin (T(2)) relaxivity (r(2)* = 176.1 mm(-1) S(-1)). The combination of the sub-100-nm particle size monodispersity in aqueous solution, superparamagnetism and fluorescent properties of the SH-SSCNs, as well as the non-cytotoxicity in vitro, provides a novel and potential candidate for an earlier MRI diagnostic method of cancer.