文献类型：期刊文献

英文题名：New triazole derivatives containing substituted 1,2,3-triazole side chains: Design, synthesis and antifungal activity

作者：Chen, Hai-Jiang[1,2];Jiang, Yan-Juan[1,2];Zhang, Yong-Qiang[3];Jing, Qi-Wei[2];Liu, Na[2];Wang, Yan[2];Zhang, Wan-Nian[2];Sheng, Chun-Quan[1,2]

机构：[1]Fujian Univ Tradit Chinese Med, Sch Pharm, 1 Qiuyang Rd, Fuzhou 350122, Fujian, Peoples R China;[2]Second Mil Med Univ, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2017

卷号：28

期号：4

起止页码：913

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402214400037)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 81573283, 21502224), the 863 Hi-Tech Program of China (No. 2014AA020525), and the Shanghai "ShuGuang" Project (No. 14SG33).

语种：英文

外文关键词：Triazole derivatives; Antifungal activities; Click reaction; Molecular docking; CYP51

摘要：In order to discover new generation of triazole antifungal agents, a series of novel antifungal triazoles were designed and synthesized by structural simplification of our previously identified triazole-piperdine-heterocycle lead compounds. Several target compounds showed good antifungal activity with a broad spectrum. In particular, compound 71 was highly active against Candida albicans and Candida glabrata. Moreover, compound 71 showed potent in vivo antifungal efficacy in the Caenorhabditis elegans-C. albicans infection model. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.