文献类型：期刊文献

英文题名：Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine

作者：Wang, Wanyan[1];Cui, Jiayan[1];Ma, Hui[1];Lu, Weiqiang[2,3];Huang, Jin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai, Peoples R China;[3]East China Normal Univ, Sch Life Sci, Shanghai, Peoples R China

年份：2021

卷号：11

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000660056400001)】；

基金：This work was funded by the National Natural Science Foundation of China (81973362, 81972828), Shanghai Committee of Science and Technology (18431900500, 19ZR1473500), and Open Research Project of Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education.

语种：英文

外文关键词：metabolic reprogram; pyrimidine metabolism; precision medicine; dihydroorotate dehydrogenase; pyrimidine inhibitor

摘要：Metabolic rewiring is considered as a primary feature of cancer. Malignant cells reprogram metabolism pathway in response to various intrinsic and extrinsic drawback to fuel cell survival and growth. Among the complex metabolic pathways, pyrimidine biosynthesis is conserved in all living organism and is necessary to maintain cellular fundamental function (i.e. DNA and RNA biosynthesis). A wealth of evidence has demonstrated that dysfunction of pyrimidine metabolism is closely related to cancer progression and numerous drugs targeting pyrimidine metabolism have been approved for multiple types of cancer. However, the non-negligible side effects and limited efficacy warrants a better strategy for negating pyrimidine metabolism in cancer. In recent years, increased studies have evidenced the interplay of oncogenic signaling and pyrimidine synthesis in tumorigenesis. Here, we review the recent conceptual advances on pyrimidine metabolism, especially dihydroorotate dehydrogenase (DHODH), in the framework of precision oncology medicine and prospect how this would guide the development of new drug precisely targeting the pyrimidine metabolism in cancer.