文献类型：期刊文献

英文题名：Optimized Synthesis of Biodegradable Elastomer PEGylated Poly(glycerol sebacate) and Their Biomedical Application

作者：Wang, Yanxiang[1,2];Wu, Haiwa[3];Wang, Zihao[1,2];Zhang, Jingjing[4];Zhu, Jing[5];Ma, Yifan[4];Yang, Zhaogang[6];Yuan, Yuan[1,2]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]Ohio State Univ, Dept Pathol, Coll Med, Columbus, OH 43210 USA;[4]Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA;[5]Ohio State Univ, Dept Pharmaceut, Coll Pharm, Columbus, OH 43210 USA;[6]Univ Texas Southwestern Med Ctr Dallas, Dept Radiat Oncol, Dallas, TX 75390 USA

年份：2019

卷号：11

期号：6

外文期刊名：POLYMERS

收录：;EI(收录号：20192507072568);WOS:【SCI-EXPANDED(收录号:WOS:000473819100037)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), National Key R&D Program of China (2018YFC1105700) and the National Natural Science Foundation of China (No. 31771040) and Leading talents in Shanghai in 2017.

语种：英文

外文关键词：poly(glycerol sebacate) (PGS); polyethylene glycol (PEG); biomedical application; biodegradable elastomer

摘要：Poly(glycerol sebacate) (PGS), a biodegradable elastomer, has been extensively explored in biomedical applications for its favorable mechanical properties and biocompatibility. Efforts have been made to fabricate multifunctional PGS copolymer in recent years, in particular PGS-co-PEG (poly(glycerol sebacate)-co-polyethylene glycol) polymers. However, rare research has been systematically conducted on the effect of reactant ratios on physicochemical properties and biocompatibility of PGS copolymer till now. In this study, a serial of PEGylated PGS (PEGS) with PEG content from 20% to 40% and carboxyl to hydroxyl from 0.67 to 2 were synthesized by thermal curing process. The effects of various PEGS on the mechanical strength and biological activity were further compared and optimized. The results showed that the PEGS elastomers around 20PEGS-1.0C/H and 40PEGS-1.5C/H exhibited the desirable hydrophilicity, degradation behaviors, mechanical properties and cell viability. Subsequently, the potential applications of the 20PEGS-1.0C/H and 40PEGS-1.5C/H in bone repair scaffold and vascular reconstruction were investigated and the results showed that 20PEGS-1.0C/H and 40PEGS-1.5C/H could significantly improve the mechanical strength for the calcium phosphate scaffolds and exhibited preferable molding capability for fabrication of the vascular substitute. These results confirmed that the optimized PEGS elastomers should be promising multifunctional substrates in biomedical applications.