文献类型：期刊文献

英文题名：Complexes of Felodipine Nanoparticles With Zein Prepared Using a Dual Shift Technique

作者：Ren, Fuzheng[1];Fu, Jinping[1];Xiong, Hui[1];Cui, Lin[1];Ren, Guobin[1];Guan, Haiying[2];Jing, Qiufang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China;[2]Shanghai SPH New Asia Pharmaceut Co Ltd, Shanghai 201203, Peoples R China

年份：2018

卷号：107

期号：1

起止页码：239

外文期刊名：JOURNAL OF PHARMACEUTICAL SCIENCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000425262500025)】；

基金：The authors gratefully acknowledge support from the Shanghai Committee of Science and Technology (grant no. 14DZ1930802) and the National Natural Science Foundation of China (grant no. 21576080).

语种：英文

外文关键词：felodipine; zein; dual shift technique; complexes; hydrophobic interaction

摘要：To improve the dissolution of felodipine, felodipine-zein complexes were prepared using a dual shift technique, with zein as both stabilizer and carrier. The complexes were characterized by particle size, zeta potential, morphology, crystalline properties, and release behavior. The complexes could be prepared in high yield and showed good redispersibility. The mean diameters of the felodipine particles in complexes were 150-300 nm, with negative zeta potentials of -30 to -25 mV after rehydration, and the particle sizes of the complexes were in the range 10-80 mu m. The size of the felodipine nanoparticles incorporated into zein increased gradually with increasing drug content. Powder X-ray diffraction and differential scanning calorimetry indicated that felodipine in the complexes was markedly less crystalline than the pure drug. Both the rate and extent of dissolution of the complexes were significantly greater than those of the active pharmaceutical ingredient or physical mixtures. Spectroscopic analyses indicated that intermolecular interactions, especially hydrophobic interactions, are the major driving forces for the formation of the felodipine nanoparticles and contribute to the stabilization effect. This study provides a promising strategy for enhancing the dissolution rate of drugs using simplified preparation processes and showcases the design of zein-based oral delivery systems for bioactive components. (c) 2018 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.