文献类型：期刊文献

英文题名：Metal-coordination synthesis of a natural injectable photoactive hydrogel with antibacterial and blood-aggregating functions for cancer thermotherapy and mild-heating wound repair

作者：Musaie, Kiyan[1];Abbaszadeh, Samin[2];Nosrati-Siahmazgi, Vahideh[1];Qahremani, Mostafa[1];Wang, Shige[3];Eskandari, Mohammad Reza[4];Niknezhad, Seyyed Vahid[5];Haghi, Fakhri[6];Li, Yulin[7];Xiao, Bo[8];Shahbazi, Mohammad-Ali[1,9,10]

机构：[1]Zanjan Univ Med Sci, Sch Pharm, Dept Pharmaceut Biomat, Zanjan 4513956184, Iran;[2]Zanjan Univ Med Sci, Sch Med, Dept Pharmacol, Zanjan 4513956111, Iran;[3]Univ Shanghai Sci & Technol, Sch Mat & Chem, 516 Jungong Rd, Shanghai 200093, Peoples R China;[4]Zanjan Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Zanjan 4513956184, Iran;[5]Univ Calif San Francisco, Dept Cell & Tissue Biol, Program Craniofacial Biol, San Francisco, CA 94118 USA;[6]Zanjan Univ Med Sci, Fac Med Sci, Dept Microbiol & Immunol, Zanjan 4513956111, Iran;[7]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ,Engn Res Ctr Bio, Shanghai 200237, Peoples R China;[8]Southwest Univ, Coll Sericulture Text & Biomass Sci, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China;[9]Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Engn, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands;[10]Univ Groningen, WJ Kolff Inst Biomed Engn & Mat Sci, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands

年份：2023

卷号：11

期号：7

起止页码：2486

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20230913636806);WOS:【SCI-EXPANDED(收录号:WOS:000930154800001)】；

基金：K. M. acknowledges the financial support from the School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran, under the framework of the thesis project (No. A-12-1296-7) with the ethical code of IR.ZUMS.REC.1399.070. Prof. M.-A. S. acknowledges the Iran National Science Foundation-National Natural Science Foundation of China joint grant (No. 4001987) and the Incentive fund from the University of Groningen.

语种：英文

外文关键词：Allantoin - Bismuth compounds - Blood - Cell proliferation - Coordination reactions - Diseases - Hydrogels - Hyperthermia therapy - Repair - Sodium alginate - Tumors

摘要：Photothermal therapy (PTT) is a promising approach for treating cancer. However, it suffers from the formation of local lesions and subsequent bacterial infection in the damaged area. To overcome these challenges, the strategy of mild PTT following the high-temperature ablation of tumors is studied to achieve combined tumor suppression, wound healing, and bacterial eradication using a hydrogel. Herein, Bi2S3 nanorods (NRs) are employed as a photothermal agent and coated with hyaluronic acid to obtain BiH NRs with high colloidal stability. These NRs and allantoin are loaded into an injectable Fe3+-coordinated hydrogel composed of sodium alginate (Alg) and Farsi gum (FG), which is extracted from Amygdalus scoparia Spach. The hydrogel can be used for localized cancer therapy by high-temperature PTT, followed by wound repair through the combination of mild hyperthermia and allantoin-mediated induction of cell proliferation. In addition, an outstanding blood clotting effect is observed due to the water-absorbing ability and negative charge of FG and Alg as well as the porous structure of hydrogels. The hydrogels also eradicate infection owing to the local heat generation and intrinsic antimicrobial activity of the NRs. Lastly, in vivo studies reveal an efficient photothermal-based tumor eradication and accelerated wound healing by the hydrogel.