文献类型：期刊文献

英文题名：Effects of lead, mercury, aluminium and manganese co-exposure on the serum BDNF concentration of pre-school children in Taizhou, China

作者：Zhou, Can-Can[1];Gao, Zhen-Yan[1,2];He, Yu-Qiong[3];Wu, Mei-Qin[1];Chen, Fei[4];Wang, Ju[1];Liu, Jun-Xia[1];Yan, Chong-Huai[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE Shanghai Key Lab Childrens Environm Hlth, Shanghai 200092, Peoples R China;[2]Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai 200040, Peoples R China;[3]Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China;[4]East China Univ Sci & Technol, Shanghai 200237, Peoples R China

年份：2019

卷号：217

起止页码：158

外文期刊名：CHEMOSPHERE

收录：;EI(收录号：20184806154284);WOS:【SCI-EXPANDED(收录号:WOS:000456223500019)】；

基金：This work was supported by the National Basic Research Program of China (973 Program, 2012CB525001) and the National Natural Science Foundation of China (Grant No. 81472993).

语种：英文

外文关键词：Lead; Mercury; Aluminium; Manganese; BDNF; Gender

摘要：Previous studies have shown that toxic metal exposure can have adverse effects on the nervous system of children, but the toxicology of metal co-exposure on neurodevelopment remains to be clarified. Brain derived neurotrophic factor (BDNF) plays an important role in nervous system development, but the possible effects of metal co-exposure on the serum BDNF concentrations of children remain unknown. A total of 561 children living in Taizhou City, China were recruited to participate in our cross-sectional multicenter survey. We measured their blood Pb, Hg, Al and Mn levels and serum BDNF concentrations as well as determined their associations in the total and within sex subgroups. The geometric means of the blood Pb, Hg, Al and Mn levels in all the participants were 67.18 mu g/L, 1.01 mu g/L, 52.03 mu g/L and 18.26 mu g/L, respectively. The serum BDNF concentration in children was 19.45 ng/mL. After adjusting for confounders, the blood Pb levels were significantly negatively associated with the serum BDNF concentrations in all the subjects and boys but not in girls. In addition, a significantly negative interaction between blood Pb and blood Hg and a positive interaction between blood Pb and blood Al on serum BDNF concentrations were also observed in boys but not in girls. Our findings highlight the toxic effects of metal co-exposure on serum BDNF levels in pre-school children and indicate that these effects might differ by gender, which suggest that special attention should be paid to the sex-specific effects of metal exposure. (C) 2018 Elsevier Ltd. All rights reserved.