文献类型：期刊文献

英文题名：A cyclin-like protein, ClgA, regulates development in Aspergillus nidulans

作者：Yu, Zhenzhong[1];Cai, Menghao[1];Hu, Wei[1];Zhang, Ying[1];Zhou, Jiao[1];Zhou, Xiangshan[1];Zhang, Yuanxing[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2014

卷号：165

期号：6

起止页码：462

外文期刊名：RESEARCH IN MICROBIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000347626000008)】；

基金：This work was supported by National Natural Science Funds of China (31270141, 41306121). We thank Prof. Reinhard Fisher, Karlsruhe Institute of Technology, for helpful technical direction.

语种：英文

外文关键词：Asexual development; Sexual development; Cyclin-like protein; Temperature sensitive

摘要：A cyclin-like protein from Aspergillus nidulans, ClgA, was identified. Its cyclin-like subunit shares 28.3% identity to Saccharomyces cerevisiae Clg1. Deletion of clgA slightly influenced fungal growth, but repressed asexual development and made it more sensitive to temperature variations. It also downregulated expression of brlA, abaA and wetA, which are critically responsible for asexual development. Sexual development was impaired in the Delta clgA mutant. Its related genes, veA and nosA, were expressed weakly in the Delta clgA mutant, while nsdD expression showed the opposite behavior. Generally, ClgA functioned differently from other reported cyclins in development of A. nidulans. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.