文献类型：期刊文献

英文题名：Regioselective Cu(I)-Catalyzed Tandem A³-Coupling/Decarboxylative Coupling to 3-Amino-1,4-Enynes

作者：Feng, Huangdi[1,2];Ermolat'ev, Denis S.[1];Song, Gonghua[2];Van der Eycken, Erik V.[1]

机构：[1]Katholieke Univ Leuven, Dept Chemstry, Lab Organ & Microwave Assisted Chem LOMAC, B-3001 Louvain, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2012

卷号：14

期号：7

起止页码：1942

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000302387800073)，CCR-EXPANDED(收录号:WOS:000302387800073)】；

基金：The authors wish to thank the FWO (Fund for Scientific Research-Flanders (Belgium)) and the Research Fund of the Katholieke Universiteit Leuven and the Industrial Research Fund of the Katholieke Universiteit Leuven for financial support to the laboratory. D.S.E. is grateful to the FWO for obtaining a postdoc fellowship. H.D.F. thanks the China Scholarship Council for financial support.

语种：英文

摘要：An efficient and novel copper-mediated protocol for the synthesis of 3-amino-1,4-enynes from glyoxylic acid, an amine, and an alkyne was developed. This new reaction involving two sequential C-C bond formations is air and moisture tolerant and proceeds via a tandem A(3)-coupling and a selective decarboxylative coupling.