文献类型：期刊文献

英文题名：Effects of Dopamine and Serotonin Systems on Modulating Neural Oscillations in Hippocampus-Prefrontal Cortex Pathway in Rats

作者：Xu, Xiaxia[1,2];Zheng, Chenguang[1,2,3];An, Lei[1,2];Wang, Rubin[4];Zhang, Tao[1,2]

机构：[1]Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China;[2]Nankai Univ, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China;[3]Univ Texas Austin, Ctr Learning & Memory, Austin, TX 78712 USA;[4]E China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai 200237, Peoples R China

年份：2016

卷号：29

期号：4

起止页码：539

外文期刊名：BRAIN TOPOGRAPHY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000377355700005)】；

基金：This work was supported by Grants from the National Natural Science Foundation of China (11232005, 31171053), and 111 Project (B08011).

语种：英文

外文关键词：Ventral hippocampus; Prefrontal cortex; Theta rhythm; Gamma oscillations; Dopamine; 5-HT

摘要：Theta and gamma oscillations are believed to play an important role in cognition and memory, and their phase coupling facilitates the information transmission in hippocampal-cortex network. In a rat model of chronic stress, the phase coupling of both theta and gamma oscillations between ventral hippocampal CA1 (vCA1) and medial prefrontal cortex (mPFC) was found to be disrupted, which was associated with the impaired synaptic plasticity in the pathway. However, little was known about the mechanisms underlying the process. In order to address this issue, both dopamine and serotonin as monoaminergic neurotransmitters were involved in this study, since they were crucial factors in pathological basis of depressive disorder. Local field potentials (LFPs) were recorded simultaneously at both vCA1 and mPFC regions under anesthesia, before and after the injection of dopamine D1 receptor antagonist and 5-HT1A receptor agonist, respectively. The results showed that the blockage of D1 receptor could lead to depression-like decrement on theta phase coupling. In addition, the activation of 5-HT1A receptor enhanced vCA1-mPFC coupling on gamma oscillations, and attenuated CA1 theta-fast gamma cross frequency coupling. These data suggest that the theta phase coupling between vCA1 and mPFC may be modulated by dopamine system that is an underlying mechanism of the cognitive dysfunction in depression. Besides, the serotonergic system is probably involved in the regulation of gamma oscillations coupling in vCA1-mPFC network. [GRAPHICS] .