文献类型：期刊文献

英文题名：The research and preparation of a novel nano biodegradable polymer external reinforcement

作者：Zhang, Xiangman[1];Chen, Bin[1];Fu, Weiguo[1];Fang, Zhengdong[1];Liu, Zhenjie[1];Lu, Weifeng[1];Shi, Zhengyu[1];Chen, Lili[2];Chen, Tao[2]

机构：[1]Fudan Univ, Zhongshan Hosp, Dept Vasc Surg, Shanghai 200032, Peoples R China;[2]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2011

卷号：258

期号：1

起止页码：196

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20114314447670);WOS:【SCI-EXPANDED(收录号:WOS:000296492500033)】；

基金：The authors gratefully acknowledge funding from the National High Technology Research and Development Program of China (2007AA03Z429) and the Nature Science Foundation of China (30972943/C160405).

语种：英文

外文关键词：Electrospun; Micelles; Tissue engineering

摘要：The use of current drug-loaded vascular scaffolds is limited in sustained drug release and stability studies in clinical and preclinical trials. We found that poly(l-glutamic acid)-b-poly(propylene oxide)-b-poly(l-glutamic acid) (PLGA-b-PPO-b-PLGA) triblock copolymers can deliver multiple poorly water-soluble drugs (e.g., Paclitaxel) at clinically relevant doses. In this study, we synthesized a new drug-loaded vascular external graft with electrospun nanofibrous scaffolds [poly(l-lactide-co-epsilon-caprolactone) (PLCL):fibrinogen; 2:1 (w/w)] and drug-loaded PLGA-b-PPO-b-PLGA micelles. Cell proliferation and viability assay results showed that beagle smooth muscle cells grew well on the surface of vascular graft-coated micelles at a percentages of 10% (w/w) GPG: PLCL-fibrinogen. This study demonstrates that micelle-coated electrospun PLCL-fibrinogen vascular scaffolds have potential applications in vascular tissue engineering. (C) 2011 Elsevier B.V. All rights reserved.