文献类型：期刊文献

中文题名：气相色谱-质谱联用测定氘标记卤代苯及其衍生物的同位素丰度

英文题名：Isotope Abundance Detection of Deuterium Labeled Halogenobenzene and Its Derivatives by GC-MS

作者：雷雯[1,2];侯捷[1];杜晓宁[1];张维冰[2]

机构：[1]上海化工研究院上海稳定性同位素工程技术研究中心,上海200062;[2]华东理工大学化学与分子工程学院,上海200237

年份：2015

卷号：37

期号：10

起止页码：903

中文期刊名：化学试剂

外文期刊名：Chemical Reagents

收录：CSTPCD;;北大核心:【北大核心2014】；

基金：上海市科技人才计划博士后基金资助项目(14-R21421800);上海市科委技术标准专项基金资助项目(13DZ-0502601);科技部专项基金资助项目(2014EG116258)

语种：中文

中文关键词：同位素丰度;氘标记;溴苯-D5;气质联用(GC-MS);EI质谱

外文关键词：isotope abundance; deuterium labeled; bromobenzene-D5; GC-MS; EI spectrum

摘要：稳定同位素氘标记卤代苯及其衍生物是一类重要的氘标记基础试剂。以溴苯-D5为例,开发了基于气质联用的氘标记卤代苯及其衍生物同位素丰度表征方法,考查了样品配制溶剂和配制浓度对同位素丰度值的影响,在优化的测试条件下,所发展的方法具有良好精密度和准确度。最后,对上海化工研究院研制的氘标记实际样品溴苯-D5、4-硝基溴苯-D4和4,4'-二硝基二苯硫醚-D8的同位素丰度进行了测定,分别为99.6 atom%、99.5 atom%和99.1 atom%。该方法能够快速、准确、高效地测定氘标记卤代苯及其衍生物的同位素丰度。
Stable isotope deuterium labeled halogenbenzene and its derivatives are useful and important basic reagent. In this work,analytical method of the isotope abundance for deuterium labeled halogenbenzene and its derivatives was developed. Taking bromobenzene-D5 as example,the effect of sample concentration and different solvent on determination of isotope abundance has been investigated. Stable isotope labeled bromobenzene-D5,1-bromo-4-nitrobenzene-D4 and 4-nitrophenyl disulfide-D8 developed by Shanghai Research Institute of Chemical Industry have been determined by the new method,which isotope abundance were99. 6 atom%,99. 5 atom% and 99. 1 atom%. It is a rapid and accurate method for determination of isotope abundance of deuterium labeled halogenbenzene and its derivatives.