文献类型：期刊文献

中文题名：聚羟基丙酸乙酸膜的降解

英文题名：Degradation of PLGA Film

作者：唐智荣[1];黄虹[2];饶炬[1];程树军[1]

机构：[1]华东理工大学材料科学研究所,上海200237;[2]上海信息技术学院,上海200331

年份：2002

卷号：28

期号：4

起止页码：383

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：2002447167720);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：聚羟基丙酸乙酸膜;药物控制释放;玻璃化温度;降解机理;生物降解型聚酯;生物材料

外文关键词：poly(lactic acid co glycolic acid); drug controlled release; glass transition temperature; degradation mechanism

摘要：以 GPC、NMR及 DSC等分析方法 ,研究了聚羟基丙酸乙酸 (PLGA)降解过程中 ,相对分子质量及其分布、吸水率、失重及玻璃化温度的变化 ,并探讨了 PLGA的体外降解机理。结果表明 :降解温度高于 1 0°C时 ,PLGA进行均相降解 ;温度低于 1 0°C时 。
Poly(lactic acid co glycolic acid), a biodegradable material, was widely applied in the field of system. In this paper, changes of molecular weight, molecular weight distribution, water absorption, polymer weight loss and glass transition temperature of PLGA during the degradation process were studied, and the degradation mechanism in vitro was also discussed. The results show that when the temperature is higher than 10°C, the PLGA film processes homogeneous degradation; on the contrary, it processes heterogeneous degradation.