文献类型：期刊文献

英文题名：Strategy for the improvement of prodigiosin production by a serratia marcescens mutant through fed-batch fermentation

作者：Tao, Jin-Li[1]; Wang, Xue-Dong[1]; Shen, Ya-Ling[1]; Wei, Dong-Zhi[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, Institute of Biochemistry, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China

年份：2005

卷号：21

期号：6-7

起止页码：969

外文期刊名：World Journal of Microbiology and Biotechnology

收录：EI(收录号：2005489517840)

语种：英文

外文关键词：Carbon - Fermentation - Glycerol - Productivity - Ultraviolet radiation

摘要：A Serratia marcescens mutant for prodigiosin production was obtained by u.v. mutation with rational screening methods and a two-step feeding strategy was used to increase its productivity. In flasks, the mutant strain B6 gave a 2.8-fold higher prodigiosin production than that of the parent strain with glycerol as a carbon source. In a 5-l bioreactor, with a two-step feeding strategy in which glucose was selected as the initial carbon source in the fermentation media and glycerol was fed as a 'prodigiosin inducer', it gave a 7.8 times higher prodigiosin production (583 mg/l) than the parent stain with the original cultivation mode. ? Springer 2005.