文献类型：期刊文献

英文题名：Chiral iminophosphoranes organocatalyzed asymmetric hydroxylation of 3-substituted oxindoles with oxaziridines

作者：Li, Baocheng[1,2];Xu, Zhen-Jiang[1,2];Han, Jianwei[1,2,3]

机构：[1]Shanghai Inst Technol, Sch Chem & Environm Engn, 100 Haiquan Rd, Shanghai 201418, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Ling Ling Rd, Shanghai 200032, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：59

期号：25

起止页码：2412

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000434902200007)，CCR-EXPANDED(收录号:WOS:000434902200007)】；

基金：This work was supported by grants from National Natural Science Foundation of China (NSFC, 21472213, 21472216). National Key Program (2016YFA0200302, Study on application and preparation of aroma nanocomposites) as well as by Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant. We thank Professor Henry N. C. Wong for helpful discussion and generous support.

语种：英文

外文关键词：Organocatalysis; Superbase; Iminophosphorane; Oxindoles; Hydroxylation

摘要：Enantioselective hydroxylation of N-protected 3-substituted oxindoles has been developed via chiral iminophosphorane catalysis with oxaziridines as oxidants. As such, a variety of optically active 3-substituted-3-hydroxy-2-oxindoles were obtained in excellent yields (91-99%) and moderate to excellent level of enantiomeric excess (up to 94% ee). (C) 2018 Elsevier Ltd. All rights reserved.