文献类型：期刊文献

英文题名：Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases

作者：Du, Wei[1];Zou, Zhen-Ping[1];Ye, Bang-Ce[1];Zhou, Ying[1]

机构：[1]East China Univ Sci & Technol, Lab Biosyst & Microanal, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：17

期号：1

外文期刊名：GUT MICROBES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001472619000001)】；

基金：This work was sponsored by the National Key Research and Development Program of China [2023YFF1204500], the National Natural Science Foundation of China [22134003], and China Postdoctoral Science Foundation [2023M741176, 2024T170274].

语种：英文

外文关键词：High-fat diets; chronic diseases; gut microbiota; metabolites

摘要：Excessive intake of dietary fats is strongly associated with an increased risk of various chronic diseases, such as obesity, diabetes, hepatic metabolic disorders, cardiovascular disease, chronic intestinal inflammation, and certain cancers. A significant portion of the adverse effects of high-fat diet on disease risk is mediated through modifications in the gut microbiota. Specifically, high-fat diets are linked to reduced microbial diversity, an overgrowth of gram-negative bacteria, an elevated Firmicutes-to-Bacteroidetes ratio, and alterations at various taxonomic levels. These microbial alterations influence the intestinal metabolism of small molecules, which subsequently increases intestinal permeability, exacerbates inflammatory responses, disrupts metabolic functions, and impairs signal transduction pathways in the host. Consequently, diet-induced changes in the gut microbiota play a crucial role in the initiation and progression of chronic diseases. This review explores the relationship between high-fat diets and gut microbiota, highlighting their roles and underlying mechanisms in the development of chronic metabolic diseases. Additionally, we propose probiotic interventions may serve as a promising adjunctive therapy to counteract the negative effects of high-fat diet-induced alterations in gut microbiota composition.