文献类型：期刊文献

英文题名：A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions

作者：Chen, Junwei[1,2];Wang, Na[1,2];Tong, Hongjuan[3];Song, Chao[1,2];Ma, Huijuan[1,2];Zhang, Yajun[1,2];Gao, Feng[1,2];Xu, Huan[1,2];Wang, Wei[1,2,4,5];Lou, Kaiyan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Shaanxi Inst Int Trade & Commerce, Sch Pharm, Collaborat Innovat Ctr Green Mfg Technol Tradit C, Xian 712046, Peoples R China;[4]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA;[5]Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

年份：2021

卷号：32

期号：12

起止页码：3876

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000771784000031)】；

基金：The work was supported by the National Natural Science Foundation of China (Nos. 21577037 and 21738002), the State Key Laboratory of Bioreactor Engineering, Shanghai Natural Science Fund (No. 20ZR1414700) and Shanghai Sailing Program (No. 19YF1412500), Natural Science Basic Research Program of Shaanxi (No. 2019JQ-924), Key Breeding Program by Collaborative Innovation Center of Green Manufacturing Technology for Traditional Chinese Medicine in Shaanxi Province (No. 2019XT-1-03).

语种：英文

外文关键词：Fluorescent probe; Circular dichroism; Heavy metal ions; Dual-modality; Detoxification; Cascade reaction; Divergent responses

摘要：Selective detection of multiple analytes in a compact design with dual-modality and theranostic features presents great challenges. Herein, we wish to report a coumarin-thiazolidine masked (D)-penicillamine based dual-modality fluorescent probe COU-DPA-1 for selective detection, differentiation, and detoxification of multiple heavy metal ions (Ag+, Hg2+, Cu2+). The probe shows divergent fluorescence (FL)/circular dichroism (CD) responses via divergent bond-cleavage cascade reactions (metal ion promoted C-S cleavage and hydrolysis at two distinctive cleavage sites): FL "turn-off" and CD "turn-on" for Ag+ (no hydrolysis), FL "turn-on" and CD "turn-off" for Hg2+ (imine hydrolysis), and FL "self-threshold ratiometric" and CD "turn-off" for excess Cu2+ (lactone and imine hydrolysis), providing the first example of a fluorescence/CD dual-modality probe for multiple species with complimentary responses. Moreover, the bond-cleavage cascade reactions also lead to the formation of (D)-penicillamine heavy metal ion complexes for potential detoxification treatments. (C) 2021 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.