文献类型：期刊文献

英文题名：Dual-stimuli responsive nanoparticles (UCNP-CD@APP) assembled by host-guest interaction for drug delivery

作者：Hao, Weiju;Liu, Danyang;Wang, Yizhou;Han, Xia;Xu, Shouhong[1];Liu, Honglai

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Coll Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：537

起止页码：446

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20174404316637);WOS:【SCI-EXPANDED(收录号:WOS:000417068300051)】；

基金：Financial support for this work was provided by the National Natural Science Foundation of China (No. 21376073, 91334203, 21276074).

语种：英文

外文关键词：UCNPs; pH-sensitive; Photo-trigger; Host-guest; Drug delivery

摘要：In this paper, dual-sensitive nanoparticles with pH-and photo-responsibility were prepared through host-guest interaction. Self-synthesized copolymer azobenzene -poly-2-(diisopropylamino) ethyl methacrylate - methoxypolyethylene glycols (AZO-PDPA(n)-PEG(45), APP) acted as a guest and inserted into the host cyclodextrins (beta-CD) automatically, which had been grafted onto the surface of upconversion nanoparticle (UCNP-CD). The insertion of APP was reversibly due to the alternating cis-trans isomerism of AZO under UV and Vis light, which produced simultaneously by UCNP when irradiated by near-infrared (NIR, 980 nm). And, the PDPA block provided a pH sensitive "lock" for releasing cargos. The self-assembled UCNP-CD@APPs were tried to incorporate anti-cancer drug DOX and were proved to release DOX controllably under stimulus of pH and NIR. During the whole process, the reversible isomerism behavior of AZO acted as a 'perpetual stirrer' resulting in a quick release. The UCNPCD@APP nanoparticles displayed good biocompatibility via MTT assay. Meanwhile, the DOX loaded in UCNPCD@APP exhibited an obvious cytotoxic effect on HeLa cells than free DOX.