文献类型：期刊文献

英文题名：Electrochemical Sensing in Contact Lenses

作者：Liu, Huixin[1,2];Yan, Xiaomei[3];Gu, Zhen[4];Xiu, Guangli[1,2];Xiao, Xinxin[3]

机构：[1]East China Univ Sci & Technol, Sch Resources & Environm Engn, Shanghai Environm Protect Key Lab Environm Standa, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, Shanghai 200237, Peoples R China;[3]Tech Univ Denmark, Dept Chem, DK-2800 Lyngby, Denmark;[4]East China Univ Sci & Technol, Sch Informat Sci & Engn, Dept Automat, Shanghai 200237, Peoples R China

年份：2022

卷号：34

期号：2

起止页码：227

外文期刊名：ELECTROANALYSIS

收录：;EI(收录号：20231713999519);WOS:【SCI-EXPANDED(收录号:WOS:000683608500001)】；

基金：This work was supported by Shanghai Science and Technology Commission (20DZ1204006, 19DZ1205007). X.X. acknowledges a Villum Experiment (grant No. 35844). X.Y. thanks the support from the China Scholarship Council (201806650009).

语种：英文

外文关键词：Contact lens; Point-of-care; Electrochemical sensor; Enzymatic biosensor

摘要：Electrochemical sensors embedded in hydrogel-based contact lenses provide valuable health-related information, enabling non-invasive and real-time continuous monitoring. Recently, considerable progress has been made in tear based electrochemical sensors. The scope of reported analytes is continuously expanding. This review identifies key chemical biomarkers (including metabolites, ions, proteins) that can be electrochemically detected in tears. The working principles of i) amperometric enzymatic biosensors, ii) ion-selective sensors for pH and ions, iii) voltammetric sensors and iv) affinity sensors are summarized. This review provides guidelines for the future development of contact lens based electrochemical sensors.