文献类型：期刊文献

英文题名：Synthesis of Polysubstituted 3-Aminothiophenes from Thioamides and Allenes via Tandem Thio-Michael Addition/Oxidative Annulation and 1,2-Sulfur Migration

作者：Han, Teng;Wang, Yu;Li, Hong-Liang;Luo, Xiaoyan[1];Deng, Wei-Ping[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2018

卷号：83

期号：3

起止页码：1538

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20180604762455);WOS:【SCI-EXPANDED(收录号:WOS:000424729400049)，CCR-EXPANDED(收录号:WOS:000424729400049)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21572053) and Natural Science Foundation of Shanghai (No. 17ZR1407600).

语种：英文

外文关键词：Organic compounds

摘要：A facile synthetic method for the construction of 3-aminothiophenes from readily available thioamides and alllenes in the presence of a TBAI/TBHP catalyst system was developed. This protocol represents an efficient and straightforward way to access highly functionalized thiophenes in moderate to excellent yields under mild conditions, via a tandem thio-Michael addition, oxidative annulation, and 1,2-sulfur migration pathway.