文献类型：期刊文献

英文题名：Copper-Doped Bioactive Glass-Coating with Immune-Enhancing Effect to Enhance Antimicrobial Activity and Osseointegration

作者：Huo, Shicheng[1]; Lyu, Zhuocheng[2]; Su, Xinjin[3]; Wang, Fan[7]; Liu, Jia[1]; Liu, Shu[8]; Zhang, Jue[6]; Zheng, Kai[4,5]; Xu, Guohua[1]

机构：[1] Department of Orthopedic Surgery, Spine Center, Changzheng Hospital, Navy Medical University, Shanghai, 200003, China; [2] Department of Bone and Joint Surgery, Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China; [3] Department of Spine Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; [4] Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing, 210029, China; [5] Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China; [6] Oral Disease Research Center, School of Stomatology, Wannan Medical College Wuhu, Wuhu, 241000, China; [7] Key Laboratory for Ultrafine Materials, Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China; [8] Changhai Hospital, China

年份：2022

外文期刊名：SSRN

收录：EI(收录号：20220286093)

语种：英文

外文关键词：Arthroplasty - Bioactive glass - Coatings - Deposition - Electrophoresis - Metal ions - Metals - Topography

摘要：Implant-related infection (IRI) is a disastrous complication after total joint arthroplasty (TJA). Due to its cytocompatibility and mechanically resistance, titanium (Ti), has been recognized as suitable bone implant materials. However, Ti lacks bioactivity and is prone to inducing bacterial infection. In this study, we developed an innovative surface coating using electrophoretic deposition (EPD) to overcome those limitations. The coating was composedof (i) a natural biocompatibility polymer Chitosan (Chit), and (ii) a novel copper-doped bioactive glass nanoparticles (Cu-BGNs) with antibacterial and pro-osteogenic properties. In vitro experiments showed that this coating endowed the Ti surface with the ability to promote macrophage M1 polarization through topography and released copper ions. Combining immunoregulatory antibacterial effects with transient bactericidal activity led to synergetic effects against IRIs of the coating. Furthermore, the coated Ti implants exert favorable osteo-immunomodulatory effects towards enhanced osteogenic abilities as evidenced in vitro and in vivo. This strategy combining Cu-BGNs-Chit composites and EPD provides novel theories and methods for designing and fabricating immunomodulatory implants targeting IRIs. ? 2022, The Authors. All rights reserved.