文献类型：期刊文献

英文题名：Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy

作者：Hu, Zhichao[1];Lu, Jiaqi[1];Hu, Annan[1];Dou, Yongjiang[2];Wang, Sheng[2];Su, Dihan[1];Ding, Wang[4];Lian, Ruixian[3];Lu, Shunyi[1];Xiao, Lan[7];Li, Yu-Lin[3];Dong, Jian[1,5,6];Zhou, Jian[1];Yang, Xuyong[2];Jiang, Libo[1]

机构：[1]Fudan Univ, Zhongshan Hosp, Dept Orthopaed Surg, Shanghai 200032, Peoples R China;[2]Shanghai Univ, Key Lab Adv Display & Syst Applicat, Minist Educ, Shanghai 200072, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]Fudan Univ, Minhang Hosp, Dept Orthoped Surg, Shanghai 201100, Peoples R China;[5]Fudan Univ, Zhongshan Hosp, Canc Ctr, Shanghai 200032, Peoples R China;[6]Fudan Univ, Zhongshan Hosp Wusong Branch, Dept Orthopaed Surg, Shanghai 200940, Peoples R China;[7]Queensland Univ Technol, Ctr Biomed Technol, Sch Mech Med & Proc Engn, Brisbane, Qld 4059, Australia

年份：2022

卷号：446

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20222512241673);WOS:【SCI-EXPANDED(收录号:WOS:000810328500001)】；

基金：This work was supported by "Technology Innovation Action Plan" of Science and Technology Commission of Shanghai Municipality (21S11902700), Natural Science Foundation of Shanghai (21ZR1412300), National Natural Science Foundation of China (No. 81972508, 82172738), Shanghai Talent Development Fund (2020067), Shanghai "Rising Stars of Medical Talent" Youth Development Program (Youth Medical Talents-Specialist Program, [2020]087), Shanghai Sailing Program (No. 19YF1406800). The authors are grateful to Ms. Xiao Guo in the Joint Live Small Animal Imaging Laboratory of Fudan University Shanghai Medical College-PerkinElmer Company, for her technical support in the use of high-resolution X-ray micro-CT scanning.

语种：英文

外文关键词：Hydrogel; Scaffold; Silk fibroin; Delignified wood; Bone repair

摘要：Bone regeneration following the removal of tumor tissues remains a major clinical challenge for the treatment of bone defects, in which materials with combinatory bone repair and osteolytic metastasis therapy is considered as a promising solution. Herein, a highly strong delignified wood/regenerated silk fibroin (RSF) hydrogel scaffold integrated with black phosphorus quantum dots (BPQDs) encapsulated by poly (lactic-co-glycolic acid) (PLGA) was engineered to realize efficient mechanical supporting, bone regeneration, and tumor therapy. Following delignification, the white wood (WW) scaffold significantly improved the mechanical properties of RSF composite hydrogel, with the elastic modulus in the L-direction and R-direction of 300 MPa and 3.3 MPa, and compression modulus in the L-direction of 9.3 MPa. Moreover, the WW/RSF hydrogel scaffold with BPQD/PLGA nanospheres effectively promoted the proliferation, migration, and osteogenic differentiation of bone mesenchymal stem cells and enhanced osteogenesis in vivo. Compared with the vertical implantation method, better bone regeneration was observed in parallel implantation system parallel to bone shaft. Importantly, the BPQDs in the hydrogel scaffolds could inhibit osteoclast differentiation and exhibit photothermal effects against metastatic tumor in the spine. Our data provide promising evidence for the potential therapeutic application on bone regeneration and ablation of bone metastasis.