文献类型：期刊文献

英文题名：Biodegradable Nanoparticles of Polyacrylic Acid-Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition

作者：Xu, Chengyuan[1];Yan, Yunfeng[2];Tan, Jinchao[3];Yang, Dahai[3];Jia, Xianjing[6];Wang, Lu[2];Xu, Yisheng[4];Cao, Song[1];Sun, Shengtong[5]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[5]Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Ctr Adv Low Dimens Mat, Shanghai 201620, Peoples R China;[6]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2019

卷号：29

期号：24

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20191706816181);WOS:【SCI-EXPANDED(收录号:WOS:000471074000022)】；

基金：C.X. and Y.Y. contributed equally to this work. This work was supported by National Natural Science Foundation of China (nos. 21676089, 21472043, 51873035, 21604024), and also sponsored by Shanghai Talent Development Fund (2017038), International One Belt One Road Collaboration Project of Shanghai (18490740300), 111 Project of the Ministry of Education of China (no. B08021), Natural Science Foundation of Shanghai (15ZZ030, 17ZR1440400) and "Qimingxing" project (19QA1400200), the Fundamental Research Funds for the Central Universities (222201717013), and "Chenguang Program" supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission (no. 16CG32). Y.Y. gratefully acknowledges the Open Research Fund of State Key Laboratory of Molecular Engineering of Polymers (Fudan University).

语种：英文

外文关键词：amorphous calcium carbonate; biodegradation; drug delivery; pH-responsive; tumor inhibition

摘要：Inorganic nanoparticles (NPs) are promising drug delivery carriers owing to their high drug loading efficiency, scalable preparation, facile functionalization, and chemical/thermal stability. However, the clinical translation of inorganic nanocarriers is often hindered by their poor biodegradability and lack of controlled pH response. Herein, a fully degradable and pH-responsive DOX@ACC/PAA NP (pH 7.4-5.6) is developed by encapsulating doxorubicin (DOX) in poly(acrylic acid) (PAA) stabilized amorphous calcium carbonate (ACC) NPs. The DOX-loaded NPs have small sizes (62 +/- 10 nm), good serum stability, high drug encapsulation efficiency (>80%), and loading capacity (>9%). By doping proper amounts of Sr2+ or Mg2+, the drug release of NPs can be further modulated to higher pH responsive ranges (pH 7.7-6.0), which enables drug delivery to the specific cell domains of tissues with a less acidic microenvironment. Tumor inhibition and lower drug acute toxicity are further confirmed via intracellular uptake tests and zebrafish models, and the particles also improve pharmacokinetics and drug accumulation in mouse xenograft tumors, leading to enhanced suppression of tumor growth. Owing to the excellent biocompatibility, biodegradability, and tunable drug release behavior, the present hybrid nanocarrier may find broad applications in tumor therapy.