文献类型：期刊文献

英文题名：One-pot synthesis of cis-isoquinolonic acid derivatives via three-component reaction of homophthalic anhydride with aldehydes and amines using ytterbium(III) triflate as catalyst

作者：Wang, LM; Liu, JJ; Tian, H; Qian, CT; Sun, J

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organomet Chem, Shanghai 200032, Peoples R China

年份：2005

卷号：347

期号：5

起止页码：689

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000228746200012)，CCR-EXPANDED(收录号:WOS:000228746200012)】；

语种：英文

外文关键词：cis-isoquinolonic acids; homophthalic anhydride; lanthanide triflates; Lewis acids; one-pot synthesis

摘要：Ytterbium(III) triflate efficiently catalyzes the one-pot reaction of homophthalic anhydride with aldehydes and amines at ambient temperature to afford the corresponding cis-isoquinolonic acid derivatives in good to excellent yields with high diastereoselectivity. This method provides a novel and much improved modification of the three-component reaction in terms of mild reaction conditions, short reaction times, clean reaction profiles, small quantity of catalyst, and simple work-up procedure. Another important feature of this method is that the catalyst can be easily recovered from the aqueous layer after the reaction and can be reused with no loss of activity.