文献类型：期刊文献

中文题名：A Green and Novel Method for the Synthesis of 4,4-Difluoro-3- oxo-2-（triphenylphosphoranylidene） 5-Lactones by Reformatsky Reaction

英文题名：A Green and Novel Method for the Synthesis of 4,4-Difluoro-3- oxo-2-（triphenylphosphoranylidene） 5-Lactones by Reformatsky Reaction

作者：赛达力木[1];方向[1];张栋[1];刘璐[1];吴范宏[1,2]

机构：[1]Laboratory for Advanced Material and Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China;[2]School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 200235, China

年份：2011

卷号：29

期号：12

起止页码：2713

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2011_2012】；

基金：Project supported by the National Natural Science Foundation of China （NNSFC） （Nos. 20972050, 21172148）.

语种：中文

中文关键词：aqueous medium;4-bromo-4,4-difluoro-3-oxo-2-（triphenylphosphoranylidene）butanoate;Reformatsky reaction;indium

外文关键词：aqueous medium, 4-bromo-4,4-difluoro-3-oxo-2-（triphenylphosphoranylidene）butanoate, Reformatsky reaction, indium

摘要：In the presence of In/CuCl, ethyl 4-bromo-4,4-difluoro-3-oxo-2-（triphenylphosphoranylidene）butanoate reacted with various aldehydes in aqueous medium at room temperature to give the a,a-difluorinated β-hydroxy carbonyl compounds. Furthermore, treating Reformatsky addition compounds with 1 equiv, of sodium hydroxide in the mixture of tetrahydrofuran and water afforded gem-difluoromethylenated 2-triphenylphosphoranylidene δ-lactones in excellent yields.
In the presence of In/CuCl, ethyl 4-bromo-4,4-difluoro-3-oxo-2-（triphenylphosphoranylidene）butanoate reacted with various aldehydes in aqueous medium at room temperature to give the a,a-difluorinated β-hydroxy carbonyl compounds. Furthermore, treating Reformatsky addition compounds with 1 equiv, of sodium hydroxide in the mixture of tetrahydrofuran and water afforded gem-difluoromethylenated 2-triphenylphosphoranylidene δ-lactones in excellent yields.