文献类型：期刊文献

英文题名：A novel magnetic nanoparticle as an efficient and recyclable heterogeneous catalyst for the Suzuki cross-coupling reaction

作者：Jin, Hui[1];Cui, Mengyu[1];Liu, Peiwen[1];Wang, Zhuo[1];Jin, Tongxia[1];Yang, Yonghui[1];Zhu, Weiping[1];Qian, Xuhong[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai, Peoples R China

年份：2024

卷号：9

期号：11

起止页码：2954

外文期刊名：REACTION CHEMISTRY & ENGINEERING

收录：;EI(收录号：20243516930046);WOS:【SCI-EXPANDED(收录号:WOS:001293906700001)】；

基金：The authors would like to acknowledge the financial support from the National Natural Science Foundation of China (Grants 21878088, 21476077), and the Key Project of the Shanghai Science and Technology Committee (18DZ1112703).

语种：英文

外文关键词：Addition reactions - Bioremediation - Catalysis - Hydrogenation - Magnetic nanoparticles - Photoionization - Reaction intermediates - Reaction kinetics - Synthesis (chemical)

摘要：Heterogeneous palladium catalysts are widely used in catalytic hydrogenation, oxidation, reduction, and coupling reactions due to their good stability, recyclability, and reusability. Based on the palladium ion fluorescent probe, a novel magnetically recyclable heterogeneous palladium catalyst Fe3O4@FSM@Pd was constructed and characterized, which is highly efficient and reusable for the Suzuki-Miyaura cross-coupling reaction. The subsequent series of Maitlis' filtration test, catalyst concentration-yield kinetic experiments, and phase trajectory experiments further demonstrated that Fe3O4@FSM@Pd catalyzed through a heterogeneous mechanism under selected reaction conditions. In addition, Fe3O4@FSM@Pd was applied to catalyze the synthesis of five intermediates of active pharmaceutical ingredients (APIs): valsartan, sonidegib, erdafitinib, tubulin inhibitor, and lumacaftor. Importantly, the palladium residue in the API intermediates synthesized with Fe3O4@FSM@Pd as catalyst was less than 1 ppm. Furthermore, Fe3O4@FSM@Pd is stable and can be reused at least 5 times without losing activity. A novel magnetically recyclable heterogeneous palladium catalyst Fe3O4@FSM@Pd was constructed and characterized, which is highly efficient and reusable for the Suzuki-Miyaura cross-coupling reaction.