文献类型：期刊文献

英文题名：Antioxidant and Immunomodulatory Activities of Polysaccharides from Moxa (Artemisia argyi) Leaf

作者：Lan, Min-Bo[1,2,3];Zhang, Yan-Hong[1,2];Zheng, Ying[1,2];Yuan, Hui-Hui[1,2];Zhao, Hong-Li[1,2];Gao, Feng[4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Dept Pharmaceut, Sch Pharm, Shanghai 200237, Peoples R China

年份：2010

卷号：19

期号：6

起止页码：1463

外文期刊名：FOOD SCIENCE AND BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000285906100008)】；

基金：The support of the Science and Technology Commission of Shanghai Municipality (STCSM; No. 08DZ1974000 and No. 10dz2220500) is gratefully acknowledged.

语种：英文

外文关键词：moxa leaf; polysaccharides; isolation; antioxidation; immunomodulation

摘要：The purpose of the current study was to characterize the polysaccharides isolated from the moxa (Artemisia argyi) leaf and investigate their bioactivities. The molecular weights of the purified polysaccharides were at a range from 6,000 to 10,000 Da and consisted mostly of carbohydrates (>90%), mainly the monosaccharide of xylose, arabinose, mannose, and glucose. The isolated polysaccharides were further fractionated to form 4 subtractions and all of the subfractions exhibited high antioxidant capability on both hydroxide (IC50 ranging from 8 to 18 mu g/mL) and superoxide anion radicals (IC50 ranging from 10 to 30 mu g/mL). The moxa leaf polysaccharides were also capable of enhancing the Concanavallin A (ConA)-induced T cell proliferation, but not the lipopolysaccharides (LPS)-induced B cell proliferation in the in vitro immunological tests. Furthermore, the polysaccharides also strongly facilitate ConA-induced secretion of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) in a dose-dependent manner. The results suggested that the moxa leaf polysaccharides may have potential applications as antioxidants and immune enhancers.