文献类型：期刊文献

英文题名：Polymeric micelles formed by polypeptide graft copolymer and its mixtures with polypeptide block copolymer

作者：Li, Tao[1]; Lin, Jiaping[1]; Chen, Tao[1]; Zhang, Suning[1]

机构：[1]E China Univ Sci & Technol, Key Lab Ultrafine Mat Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2006

卷号：47

期号：13

起止页码：4485

外文期刊名：POLYMER

收录：;EI(收录号：2006249937659);WOS:【SCI-EXPANDED(收录号:WOS:000238921300003)】；

语种：英文

外文关键词：polypeptide copolymer; self-assembly; micelle

摘要：Polymeric micelles based on poly(gamma-benzyl-L-glutaniate)-poly(ethylene glycol) graft copolymer (PBLG-g-PEG) with various degrees of grafting and the mixtures composed of PBLG-g-PEG and poly(gamma-benzyl-L-glutamate)-poly(ethylene glycol) block copolymer (PBLG-b-PEG) were prepared by the dialysis method in deionized water. Fluorescence spectroscopy and transmission electron microscope (TEM) have been used to study the self-assembly behavior. The experimental results revealed that the degree of grafting exerts marked effect on the critical micelle concentration (CMC) and the morphology of the micelle formed by PBLG-g-PEG. With increasing the degree of grafting, the CMC value becomes larger and the morphology of formed micelle changes from irregular shape to spindle. It was also found that mixtures of PBLG-g-PEG/PBLG-b-PEG can associate into hybrid polymeric micelle with various shapes. (c) 2006 Elsevier Ltd. All rights reserved.