文献类型：期刊文献

中文题名：异-α-姜黄烯及其衍生物的合成

英文题名：The Syntheses of Iso-α-Curcumene and its Derivatives

作者：吴达俊[1];谢文勇[1];董洁莹[1]

机构：[1]上海华东化工学院精细化工系,上海200237

年份：1992

卷号：12

期号：1

起止页码：98

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;北大核心:【北大核心1992】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金

语种：中文

中文关键词：异-α-姜黄烯;氢化;郁金;倍半萜

外文关键词：curcuma aromatic salisb;;sesquiterpenoids;;iso-α-curcumene;;hydrogenation

摘要：姜科(Zingiberaceae)姜黄属(Curcuma)是一个重要的药用植物群,其根茎和块根分别称为姜黄(或莪术)和郁金。中医中药认为,郁金具有行气、解瘀和通经等功效。动物药理试验表明,姜科植物温郁金(Curcuma
The syntheses of iso-α-curcumene (8) and its three derivatives-dehydro-iso-α-curcumene (6), 2-methyl-6-p-totyl-5-hepten-2-ol (7) and 2-methyl-6-p-totyl-2-heptanol(9) were described. The intermediate enone 4 was synthesized from p-methylacetophenonewith vinylmagnesium bromide followed by Carroll reaction with ethyl acetoacetate. Hydroge-nation of 4 led to ketone 5. 4 and 5 via Wittig reaction with Ph_3 P=CH_2 and Grignardreaction with CH_3MgI gave rise to Compounds 6, 8 and 7, 9, respectively. compounds 6and 7 have not been reported in literature. Their chemical structures were identified.