文献类型：期刊文献

英文题名：Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

作者：Oguchi, Mineki[1,2];Tanaka, Shingo[1,3];Pan, Xiaochuan[4];Kikusui, Takefumi[2];Moriya-Ito, Keiko[5];Kato, Shigeki[6];Kobayashi, Kazuto[6];Sakagami, Masamichi[1]

机构：[1]Tamagawa Univ, Brain Sci Inst, Tokyo, Japan;[2]Azabu Univ, Sch Vet Med, Sagamihara, Kanagawa, Japan;[3]Niigata Univ, Sch Med, Dept Physiol, Niigata, Japan;[4]East China Univ Sci & Technol, Inst Cognit Neurodynam, Shanghai, Peoples R China;[5]Tokyo Metropolitan Inst Med Sci, Tokyo, Japan;[6]Fukushima Med Univ, Inst Biomed Sci, Dept Mol Genet, Fukushima, Japan

年份：2021

卷号：4

期号：1

外文期刊名：COMMUNICATIONS BIOLOGY

收录：;WOS:【SSCI(收录号:WOS:000696574500004)，SCI-EXPANDED(收录号:WOS:000696574500004)】；

基金：The authors are grateful to M. Koizumi for technical assistance with the experiments. This paper was proofread in English by a native speaker from Editage (https://www.editage.jp).This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas (4303 and 4805), JSPS KAKENHI Grant Number JP18H03662 from MEXT of Japan, the National Natural Science Foundation of China (No: 11972159).

语种：英文

摘要：In order to validate a previously inferred function of the lateral prefrontal cortex (LPFC)-caudate nucleus (CdN) pathway in humans in inhibitory control and working memory, Oguchi et al used pathway-selective chemogenetic manipulation of neural activity in macaques. By suppressing pathway-specific neural activity and observing resultant behavioural changes, they provided evidence that the LPFC-CdN pathway does indeed play a role in inhibitory control. The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC-CdN pathway plays an important role in inhibitory control and working memory. We aimed to validate the function of this pathway at a causal level by pathway-selective manipulation of neural activity in non-human primates. To this end, we trained macaque monkeys on a delayed oculomotor response task with reward asymmetry and expressed an inhibitory type of chemogenetic receptors selectively to LPFC neurons that project to the CdN. Ligand administration reduced the inhibitory control of impulsive behavior, as well as the task-related neuronal responses observed in the local field potentials from the LPFC and CdN. These results show that we successfully suppressed pathway-selective neural activity in the macaque brain, and the resulting behavioral changes suggest that the LPFC-CdN pathway is involved in inhibitory control.