文献类型：期刊文献

英文题名：Enhancement Effect of Static Magnetic Field on Bactericidal Activity

作者：Zhang, Min[1,2];Song, Yongshun[1,3];Wang, Jun[4,5];Shi, Xinlei[2];Chen, Qiang[2];Ding, Rui[1];Mou, Junjie[1];Fang, Haiping[1];Zhou, Yunlong[2];Chen, Ruoyang[1]

机构：[1]East China Univ Sci & Technol, Sch Phys, Shanghai 200237, Peoples R China;[2]Univ Chinese Acad Sci, Wenzhou Inst, Zhejiang 325000, Peoples R China;[3]Changzhou Vocat Inst Ind Technol, Sch Informat Engn, Changzhou 213164, Peoples R China;[4]Shanghai Polytech Univ, Sch Energy & Mat, Shanghai 201209, Peoples R China;[5]Shanghai Engn Res Ctr Adv Thermal Funct Mat, Shanghai 201209, Peoples R China

年份：2025

卷号：21

期号：18

外文期刊名：SMALL

收录：;EI(收录号：20251218106501);WOS:【SCI-EXPANDED(收录号:WOS:001467984000001)】；

基金：This work was supported by Shanghai Pujiang Program (No. 23PJ1401800), the National Natural Science Foundation of China (12435001), the Shanghai Science and Technology Innovation Action Plan (No. 23JC1401400) and the Fundamental Research Funds for the Central Universities of East China University of Science.

语种：英文

外文关键词：antibacterial activity; paramagnetic calcium-polypyrrole nanoparticles; reactive oxygen species; static magnetic field

摘要：The biological effects of magnetic fields are pervasive in microorganisms, with significant attention given to alternating magnetic fields (AMFs). However, AMFs induce electrical and magnetothermal effects, which complicate the interpretation of magnetic field-induced biological effects and introduce uncertainties regarding cytotoxicity in practical applications. The static magnetic field (SMF) with few variables and high biocompatibility presents a promising alternative for both understanding biological mechanisms and ensuring safe applications, but has a remaining problem on weak interactions with microorganisms. Here we show that the combination of SMF with paramagnetic calcium-polypyrrole nanoparticles (Ca-PPy) remarkably enhances bactericidal activity. Our experiments indicate that the synergistic action of SMF and Ca-PPy significantly promotes the generation of reactive oxygen species (ROS), i.e., singlet oxygen and superoxide anion radicals, in Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), coupled with the physical disruption of bacterial membrane, exhibiting the extraordinary bactericidal performance (the bactericidal rate is over 94%). The mechanism disclosed by computations is that the singlet-to-triplet transition of radical pairs can be increased by the introduction of magnetic fields. These findings offer new insights into the biological effects of magnetic fields and pave the way for their safe, highly effective use in bactericidal applications.