文献类型：期刊文献

英文题名：A dual-responsive drug delivery system based on mesoporous silica nanoparticles covered with zipper-type peptide for intracellular transport/release

作者：Xu, Jun;Li, Gaoyang;Zhang, Yuhua;Kang, Yuhan;Xu, Shouhong[1];Liu, Honglai

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Key Lab Adv Mat, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：631

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20214311054840);WOS:【SCI-EXPANDED(收录号:WOS:000711437000002)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 22078087 and No. 21776071) . The authors also thank Miss Dongmei He for the advice on drawing picture.

语种：英文

外文关键词：Controlled release; Peptide; Drug delivery; Mesoporous silica; Nanocarrier

摘要：The key problem of applying mesoporous silica nanoparticles (MSNs) in drug delivery system DDS is how to block and open the porous channel controllably. In this paper, a thermo/redox dual responsive drug carrier based on MSNs has been prepared through grafting a zipper-type peptide onto MSNs surface using disulfide bond. The peptide, who has specific melting temperature Tm(43.4 degrees C), acts as a nanovalve for porous channel to block the drug in MSNs. When temperature increases above Tm, the alpha-helix structure of the peptide could turn to linear state and the nanovalve would be opened for drug release. Meanwhile, disulfide bonds between peptide and MSNs can respond to the stimulation of glutathione. The drug release experiments under different conditions were performed to prove the controllability of drug release by stimulations. And cell experiments have also been done to verify that the nanocarriers had good cytocompatibility and cell recognition. Experiments show that the drug loaded in this carrier is only released inside the tumor cells. The constructed peptide-valved MSNs might provide a special strategy for promising application of MSNs in DDS.