文献类型：期刊文献

英文题名：Versatile lifestyles of Edwardsiella: Free-living, pathogen, and core bacterium of the aquatic resistome

作者：Leung, Ka Yin[1,2];Wang, Qiyao[3,4,5];Zheng, Xiaochang[1];Zhuang, Mei[1,2];Yang, Zhiyun[1,2];Shao, Shuai[3];Achmon, Yigal[1,2];Siame, Bupe A.[6]

机构：[1]Guangdong Technion Israel Inst Technol, Biotechnol & Food Engn Program, Shantou, Peoples R China;[2]Technion Israel Inst Technol, Fac Biotechnol & Food Engn, Haifa, Israel;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[4]Shanghai Engn Res Ctr Marine Cultured Anim Vaccin, Shanghai, Peoples R China;[5]Shanghai Collaborat Innovat Ctr Biomfg, Shanghai, Peoples R China;[6]Trinity Western Univ, Dept Biol, Langley, BC, Canada

年份：2022

卷号：13

期号：1

起止页码：5

外文期刊名：VIRULENCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000736789100001)】；

基金：This research was supported by the National Natural Science Foundation of China (#31873048) to Dr. Ka Yin Leung and 2020 Li Ka Shing Foundation (LKSF) Cross-Disciplinary Research Grant (#2020LKSFG07A) to Drs. Ka Yin Leung and Yigal Achmon. Mei Zhuang received a scholarship from the Key Discipline Fund of Guangdong Province.

语种：英文

外文关键词：Edwardsiella; pathogen; free-living; aquatic resistome; virulence; antibiotic resistance genes; antibiotic resistant bacteria

摘要：Edwardsiella species in aquatic environments exist either as individual planktonic cells or in communal biofilms. These organisms encounter multiple stresses, include changes in salinity, pH, temperature, and nutrients. Pathogenic species such as E. piscicida, can multiply within the fish hosts. Additionally, Edwardsiella species (E. tarda), can carry antibiotic resistance genes (ARGs) on chromosomes and/or plasmids, that can be transmitted to the microbiome via horizontal gene transfer. E. tarda serves as a core in the aquatic resistome. Edwardsiela uses molecular switches (RpoS and EsrB) to control gene expression for survival in different environments. We speculate that free-living Edwardsiella can transition to host-living and vice versa, using similar molecular switches. Understanding such transitions can help us understand how other similar aquatic bacteria switch from free-living to become pathogens. This knowledge can be used to devise ways to slow down the spread of ARGs and prevent disease outbreaks in aquaculture and clinical settings.