文献类型：期刊文献

中文题名：丹参酮固体分散物的研究

英文题名：Study on Solid Dispersion of Tanshinone

作者：储茂泉[1];刘颂[2];古宏晨[3];刘国杰[1]

机构：[1]华东理工大学化学与制药学院,上海200237;[2]齐鲁石油化工公司第二化肥厂,淄博255400;[3]超细材料制备与应用教育部重点实验室,上海200237

年份：2001

卷号：27

期号：2

起止页码：191

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：丹参酮;聚乙烯吡喀烷酮;喷雾干燥;固体分散物;溶出度

外文关键词：tanshinone; poly (vinylpyrrolidone); spray drying; solid dispersion; solubility

摘要：应用聚乙烯吡咯烷酮 ( PVP)为载体 ,采用喷雾干燥制备了丹参酮 ( Tanshinone TAN)的固体分散物。测定了 TAN原料药、固体分散物以及机械混合物的体外溶出度 ,并通过 X-射线衍射、扫描电镜观察、以及用红外光谱和紫外光谱分析对固体分散物进行了研究。结果表明 ,TAN固体分散物的溶出度与 TAN原料药和机械混合物相比有显著提高 ;TAN以超细态分散于载体中 ;
Using poly (vinylpyrrolidone) as a carrier, solid dispersions of tanshinone were prepared by spray drying method. The solubility of the solid dispersions was detected. X Ray powder diffractometer, scanning electron microscope, IR spectrometer and UV VIS spectrophotometer were used to investigate the physical and chemical properties of the solid dispersions. The results showed that the solubility of solid dispersions was significantly increased than that of the Tanshinone and the mixtures of tanshinone and carrier. Tanshinone was present exited as ultrafine crystalline or molecular form in solid dispersions. There was no chemical reaction between tanshinone and the carrier.