文献类型：期刊文献

英文题名：Targeting integrin-rich tumors with temoporfin-loaded vitamin-E-succinate-grafted chitosan oligosaccharide/D-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles to enhance photodynamic therapy efficiency

作者：Wu, Junru[1];Feng, Shu[1];Liu, Wenchao[1];Gao, Feng[1,2,3];Chen, Yanzuo[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2017

卷号：528

期号：1-2

起止页码：287

外文期刊名：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000408007600026)】；

基金：This work was sponsored by National Natural Science Foundation of China (81503021) and the Fundamental Research Funds for the Central Universities (22A201514055 ECUST).

语种：英文

外文关键词：Temoporfin; Photodynamic therapy; Nanoparticles; Tumor targeting

摘要：A major challenge in cancer photodynamic therapy (PDT) is the poor tumor selectivity of the photosensitizer. Therefore, temoporfin (mTHPC)-loaded nanoparticles, based on vitamin-E-succinategrafted chitosan oligosaccharide and cyclic (arginine-glycine-aspartic acid-D-phenylalanine-lysine) (c [RGDfK])-modified D-a-tocopheryl polyethylene glycol 1000 succinate, were prepared (RGD-NPs) and were expected to enhance the accumulation of mTHPC in integrin-rich U87MG tumors. The RGD-NPs generated were 144.9 nm in diameter and uniformly spherical. After irradiation, RGD-NPs effectively generated singlet oxygen, and displayed enhanced cellular uptake and cytotoxicity in U87MG cells. The RGD-NPs also penetrated deep into U87MG tumor spheroids, with a tumor-targeting ability and antitumor efficacy superior to those of unmodified nanoparticles in subcutaneous-tumor-bearing nude mice. A histopathological analysis confirmed the increased anticancer efficacy of RGD-NPs, with less systemic toxicity than unmodified nanoparticles. Therefore, the RGD-NPs developed in this study potentially target integrin-rich tumors and enhance the efficiency of PDT. (C) 2017 Elsevier B. V. All rights reserved.