文献类型：期刊文献

英文题名：A fast and dual crosslinking hydrogel based on vinyl ether sodium alginate

作者：Xu, Sishi[1];Liang, Wencheng[1];Xu, Guanzhe[2];Huang, Chengjie[1];Zhang, Junyong[1];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

年份：2020

卷号：515

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20201208326389);WOS:【SCI-EXPANDED(收录号:WOS:000525637300004)】；

基金：This research was supported by the National Key Research and Development Program (2016YFC1100703).

语种：英文

外文关键词：Sodium alginate; Hydrogen bond; Thiol-ene click chemistry; Hemostasis

摘要：Optimal modification and gelation strategies of polysaccharide hydrogels have been developed for biomedical applications. Herein, a kind of fast crosslinking alginate hydrogel with superior gel properties was prepared for the first time combining dual crosslinking mechanisms. Firstly, sodium alginate (SA) was modified by vinyl ether side chains through one-step amidation reaction with aminopropyl vinyl ether (APVE) catalyzed by EDC/NHS. Just within 10 s, the grafting product of SA-VE was demonstrated to form hydrogen bonded hydrogel SA-VE/H2O spontaneously. Based on this mechanism, a dual crosslinking alginate hydrogel SA-VE/DTT was fabricated through introducing thiol-ene click chemistry reaction with dithiothreitol (DTT) under UV exposure. According to rheological results, the photo-crosslinking process was completed within 5-9 min. Combining hydrogen bonding and thiol-ene click chemistry, the dual crosslinking mechanism was proved to bring the hydrogel system not only fast gelation but also superior storage modulus up to 13373 Pa and excellent stability of over 1 month. All the hydrogels exhibited non-cytotoxicity towards NIH-3T3 fibroblasts. Furthermore, the 26 s rapid hemostasis behavior of SA-VE exhibited in rat tail hemostasis experiment reveals its potential application in wound dressing materials.