文献类型：期刊文献

英文题名：Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites

作者：Hu, Xi-Le[1,2];Zang, Yi[3];Li, Jia[3];Chen, Guo-Rong[1,2];James, Tony D.[4];He, Xiao-Peng[1,2];Tian, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2016

卷号：7

期号：7

起止页码：4004

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20162702554816);WOS:【SCI-EXPANDED(收录号:WOS:000378715000004)】；

基金：This research is supported by the 973 project (2013CB733700), the Science and Technology Commission of Shanghai Municipality (15540723800), the Shanghai Science and Technology Development Funds (14YF1413300), the Natural Science Foundation of China (21572058, 21576088 and 81302820), the National Science and Technology Major Projects (2014ZX09507-002) and the Shanghai Rising-Star Program (16QA1401400). Prof. Yi-Tao Long is warmly thanked for help in DFM. The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. T. D. J. thanks ECUST for a guest professorship.

语种：英文

外文关键词：Agglomeration - Forster resonance energy transfer - Metal nanoparticles - Gold nanoparticles - Fiber optic sensors - Fluorophores - Controlled drug delivery - Photodynamic therapy - Nanocomposites

摘要：We have developed a theranostic nanocomposite of metallic nanoparticles that uses two distinct fluorescence mechanisms: Forster Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) controlled by ligand-receptor interaction. Supramolecular assembly of the fluorophore-labeled glycoligands to cyclodextrin-capped gold nanoparticles produces a nanocomposite with a quenched fluorescence due to FRET from the fluorophore to the proximal particle. Subsequently, interaction with a selective protein receptor leads to an aggregation of the composite, reactivating the fluorescence by MEF from the distal metallic particles to fluorophores encapsulated in the aggregates. The aggregation also causes a red-shift in absorbance of the composite, thereby enhancing the production of reactive oxygen species (ROS) on red-light irradiation. Our nanocomposite has proven suitable for targeted cancer cell imaging as well as multimode therapy using both the photodynamic and drug delivery properties of the composite.