文献类型：期刊文献

英文题名：Fabrication of mesoporous calcium silicate/calcium phosphate cement scaffolds with high mechanical strength by freeform fabrication system with micro-droplet jetting

作者：Li, Cuidi[1,3];Gao, Li[1,3];Chen, Fangping[1,2];Liu, Changsheng[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：50

期号：22

起止页码：7182

外文期刊名：JOURNAL OF MATERIALS SCIENCE

收录：;EI(收录号：20153301176298);WOS:【SCI-EXPANDED(收录号:WOS:000360389300002)】；

基金：This investigation was supported by the National Basic Research Program of China (973 Program: 2012CB933600), National Natural Science Foundation of China (No. 31370960, No. 31100678), National Science & Technology Pillar Program during the Twelfth Five-years Plan Period (No. 2012BAD32B01).

语种：英文

外文关键词：Calcium silicate - Mesoporous materials - Drops - Pore size - Scaffolds (biology) - Calcium phosphate - Cements - Degradation - Solutions - Scaffolds - Silicates

摘要：In this study, we explored the feasibility of fabrication bioactive mesoporous calcium silicate/calcium phosphate cements (MCS/CPC) scaffolds with high mechanical strength by Freeform Fabrication System with Micro-Droplet Jetting. After preparation of ordered mesoporous calcium silicate (MCS) powder, ready-to-use MCS/CPC paste was formed by mixing calcium phosphate cement (CPC) powder and MCS powder with the binder polyvinyl alcohol (PVA) aqueous solution at a certain ratio of powder to liquid. MCS/CPC scaffolds with various architectures, pore sizes, and interconnectivity were then directly printed at room temperature using MCS/CPC paste. The mechanical strength, apatite formation, degradation rate, and cytocompatibility of the composite scaffolds were systematically investigated. The results showed that MCS/CPC paste exhibited outstanding printability to form MCS/CPC scaffolds. The hybrid MCS/CPC scaffolds with predefined pore size of 350 mu m showed fast degradation rate, high mechanical strength, and good cytocompatibility. It was indicated that the hybrid MCS/CPC scaffolds might be a promising candidate for critical bone defect repair.