文献类型：期刊文献

中文题名：3D打印技术用于不规则骨缺损的重建与修复

英文题名：3D printing technology for reconstruction and repair of irregular-shaped bone defects

作者：吴华初[1];张洪波[1];于凤宾[2];岑莲[1]

机构：[1]华东理工大学,化工学院,上海200237;[2]湖州市98医院,浙江湖州313000

年份：2020

卷号：37

期号：8

起止页码：1653

中文期刊名：精细化工

外文期刊名：Fine Chemicals

收录：CSTPCD;;EI(收录号：20203809190878);Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

语种：中文

中文关键词：3D打印技术;支架;骨组织工程;组织学检测;生物工程

外文关键词：3D printing technology;scaffold;bone tissue engineering;histological examination;biological engineering

摘要：为研究3D打印技术对不规则形状骨缺损模型的重建程度及3D打印的可降解生物材料对脊椎骨缺损在12周内的修复效果,随机选取1名病人,用电子计算机断层扫描(CT)数据构建出不规则的三维脊柱缺损模型,选用聚己内酯(PCL)作为支架材料,运用3D打印技术打印出高度符合该病人骨缺损部位的人工骨支架。同时建立1个简单的兔子脊椎缺损模型,以聚乳酸-羟基乙酸共聚物(PLGA)为支架材料,运用3D打印技术打印缺损尺寸的支架移植兔子体内,术后观察3个月,将兔子处死取出缺损部位,制作切片进行苏木素和伊红(H&E)染色,染色结果表明缺损部位修复良好。
To study the reconstruction degree of irregular-shaped bone defect models by 3 D printing technology and the effect of 3 D printed degradable biomaterials on the repair of vertebral bone defectsin twelve weeks,biodegradable biomaterials,polycaprolactone(PCL)was used as printing ink to print scaffold material for repair.An irregular 3 D spine defect model was constructed using computed tomography(CT)data from a randomly chosen patient.An artificial bone scaffold was printed out by 3 D printing technology,which was highly consistent with the bone defect of the patient.At the same time,a simple model of spinal defect in rabbit was established,and a defect-sized stent was printed by 3 D printing technology using poly(lactic-co-glycolic acid)(PLGA)as scaffold material and then transplanted into the rabbit.The defect was removed from the rabbit after 3 months.The sections of the defect area were made for Hematoxylin and Eosin(H&E)staining.The results indicated that 3 D printed bone scaffold was repaired well.