文献类型：期刊文献

英文题名：Molecular Logic Gate for Sensing pH/Peroxynitrite with Potential Applications in Cisplatin Treatment

作者：Guo, Lifang[1,2];Ding, Yuxi[1,2];Li, Lu[1,2];Gao, Caifang[3];Su, Jianhua[1,2];Zhang, Zhiyun[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Hosp 3,Shanxi Acad Med Sci, Taiyuan 030032, Peoples R China

年份：2024

卷号：96

期号：40

起止页码：15950

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20244117174617);WOS:【SCI-EXPANDED(收录号:WOS:001324809400001)】；

基金：We are thankful for the financial support from the NSFC/China (22474039, 22004036, 22175063, and 22335004).

语种：英文

外文关键词：Drug dosage - Drug interactions - Nitration - Nitrification - pH sensors

摘要：Cisplatin is a common chemotherapy drug for multiple solid tumors; however, due to the nitrification of peroxynitrite (ONOO-), a series of side effects seriously affect its dose and efficacy. Considering that the reactivity of ONOO- is significantly affected by pH in vitro, revealing their roles in living cells contributes to understanding the side-effect process induced by cisplatin. Herein, we present a near-infrared fluorescent logic gate for sensing pH/ONOO-, which can accurately discriminate four scenarios (no analyte, analyte H+ alone, analyte ONOO- alone, and H+ + ONOO-) and which one comes first. With this probe, the significant roles of pH and ONOO- in cisplatin treatment are disclosed, in which the cell account shows a dramatic reduction accompanied by decreased pH and upregulated ONOO- levels. By artificially recovering the pH, the ONOO- content and cell account can maintain a stable state, possibly due to the protection from acidification and nitration. This work provides an ideal pH/ONOO- logical sensor for revealing their potential roles under cisplatin, which is expected to proffer new insights into more related diseases and drug research.