文献类型：期刊文献

英文题名：Photosynthetic live microorganism-incorporated hydrogels promote diabetic wound healing via self-powering and oxygen production

作者：Wu, Yan[2];Li, Meiyun[1,2,3];He, Ruiying[3,4];Xiao, Lan[5];Liu, Sen[1,2];Chen, Kaiyuan[1,2];Qiang, Huifen[1];Ji, Keqin[1];Li, Luxin[2];Yin, Yongkui[2];Yuan, Xiaohuan[2,9];Li, Meng[6,9];Gao, Jie[1,8,9];Li, Yulin[3,7,9]

机构：[1]Naval Med Univ, Shanghai Changhai Hosp, Changhai Clin Res Unit, Shanghai, Peoples R China;[2]Mudanjiang Med Univ, Coll Life Sci, Mudanjiang, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn, Minist Educ,State Key Lab Bioreactor Engn,Key Lab, Shanghai, Peoples R China;[4]Hubei Univ, Coll Chem & Chem Engn, Wuhan, Peoples R China;[5]Griffith Univ, Sch Med & Dent, Gold Coast, Australia;[6]Shanghai Jiao Tong Univ, Dept Dermatol Shanghai Childrens Med Ctr, Sch Med, Dept Dermatol, Shanghai, Peoples R China;[7]Shanghai Univ, Wenzhou Inst, Wenzhou, Peoples R China;[8]Shanghai Key Lab Naut Med & Translat Drugs & Med D, Shanghai, Peoples R China;[9]Chinese Univ Sci & Technol, Shanghai, Peoples R China

年份：2024

卷号：485

外文期刊名：CHEMICAL ENGINEERING JOURNAL

收录：;EI(收录号：20240915643479);WOS:【SCI-EXPANDED(收录号:WOS:001197385300001)】；

基金：This research was supported by the Natural Science Foundation of Heilongjiang Province (No. LH2022H099) , the National Natural Science Fundation of China (No. 82003331, 82072051) .

语种：英文

外文关键词：Hydrogels; Chlorella; Oxygen; Diabetic wounds; Bioelectricity

摘要：Electrical stimulation and oxygen are vital for promoting cell proliferation, migration, and differentiation to repair damaged tissues in chronic wound healing in patients with diabetes. The effective oxygen production by Chlorella has garnered attention in the medical field, but the potential of extracellular electron production in skin repair has not been explored. Inspired by this, we developed CHPS hydrogels, a composite of polyacrylamide and sodium alginate, with Chlorella loaded in a semi-interpenetrating network. This network is formed by crosslinking acrylamide initiated by free radicals, with alginate chains dispersed within the network. When applied to wounds, CHPS hydrogels effectively protect damaged tissue, provide mechanical support to Chlorella against external forces, and create an optimal artificial microenvironment to promote the proliferation of Chlorella. Our study demonstrated that CHPS hydrogels exhibit remarkable fracture elongation and adhesion properties and continuously produce oxygen and bioelectrical currents through photosynthesis. Furthermore, the sustained release of dissolved oxygen and bioelectricity by CHPS hydrogels significantly enhances cell proliferation, migration, and angiogenesis, leading to improved wound healing in diabetic mice. These findings provide compelling evidence for further exploration of CHPS hydrogels as a cost-effective, simple, and accessible strategy for enhancing the clinical treatment of chronic wounds in diabetic patients.