文献类型：期刊文献

英文题名：Recent Progress in Isomerization-Based Photoacids

作者：Guo, Huichao;Gong, Guining;Chen, Yuhao;Zhang, Zhiwei[1];Zhang, Junji

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai, Peoples R China; East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Sch Ch, Inst Fine Chem,Joint Int Res Lab Precis Chem & Mol, Shanghai, Peoples R China

年份：2026

卷号：10

期号：5

外文期刊名：CHEMPHOTOCHEM

收录：;EI(收录号：20261920670054);WOS:【SCI-EXPANDED(收录号:WOS:001764953900001)】；

基金：This work is supported by the National Natural Science Foundation of China (22378121, 22478118), JZ acknowledges the Shanghai Natural Science Foundation Project (23ZR1479500, 23JC1401700). Z.Z. acknowledges the Young Elite Scientists Sponsorship Program (2023) by the Chinese Chemical Society (CCS).

语种：英文

外文关键词：isomerization; photoacid generators; photoacids; reversible photoacids

摘要：Photoacids harness light to enable precise, on-demand proton transfer and Br & oslash;nsted/Lewis acid release, laying the foundation for mimicking biological processes and unlocking novel chemical functions. Classical subfamilies-photolytic and excited-state photoacids-are valued for their high quantum yields and ease of modification. The emergence of isomerization-based photoacids has expanded this toolbox, offering unique mechanisms for reversible or irreversible light-controlled modulation of acidity. Built upon diverse photoisomerizable scaffolds such as diarylethenes and spiropyrans, these systems allow fine-tuning of pK a, activation wavelengths, and quantum yields, supporting integration into catalysis, supramolecular assembly, and bioresponsive platforms. This review systematically highlights recent advances in isomerization-based photoacids, critically examines their advantages and limitations, and provides guidelines for the rational design and application of photoisomerizable acids in future biological and materials science applications.