文献类型：期刊文献

英文题名：3D-printed air-blast microfluidic nozzles for preparing calcium alginate microparticles

作者：Ye, Biao[1];Xu, Hong[1];Bao, Binbin[1];Xuan, Jin[2];Zhang, Li[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland

年份：2017

卷号：7

期号：77

起止页码：48826

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20174404361044);WOS:【SCI-EXPANDED(收录号:WOS:000413777800033)】；

基金：Work supported by the research grant (No. 16DZ2260600) from Science and Technology Commission of Shanghai Municipality, and the Fundamental Research Funds for the Central Universities" (222201717012, 222201718005).

语种：英文

外文关键词：Calcium - Fluidic devices - Production efficiency - 3D printers - Atmospheric pressure - Particle size - Microfluidics

摘要：Microfluidic technologies have emerged as a promising route for precision fabrication of uniform particles. Equipment required for a traditional microfluidic device manufacturing process is expensive and production efficiency is low. It's also difficult to separate a surfactant and continuous phase impurities from particles prepared by a liquid-liquid two-phase shear method. A novel air-blast microfluidic nozzle fabricated using low-cost and efficient 3D printing technology was proposed to prepare calcium alginate particles. Effects of control parameters and solution composition on particle diameters and homogeneity were systematically investigated. Results showed that inlet air pressure has the most significant impact. A nozzle with an outlet diameter of 300 mm can produce particles with diameters ranging from 360 mm to 2100 mm. Coefficients of variation (CV) range from 5.3% to 2.2%. For the same diameter particle prepared, a smaller nozzle outlet had a narrower particle diameter distribution and needed lower inlet air pressure. This method can be used to handle high viscosity solutions and high concentrations of solutions with insoluble solid particles. The prepared particles can be used in biological and pharmaceutical fields.