文献类型：期刊文献

英文题名：Facile and Versatile Synthesis of Alkyl and Aryl Isothiocyanates by Using Triphosgene and Cosolvent

作者：Liu, Pengfei[1];Li, Chunyan[1];Zhang, Jingwei[1];Xu, Xiaoyong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2013

卷号：43

期号：24

起止页码：3342

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242716638418);WOS:【SCI-EXPANDED(收录号:WOS:000323999500013)，CCR-EXPANDED(收录号:WOS:000323999500013)】；

基金：This work was financially supported by the National Natural Science Foundation of China (21272071), the National Basic Research Program of China (973 Program, 2010CB126100), and the National High Technology Research and Development Program of China (863 Program, 2011AA10A207). This work was also partly supported by the National Key Technology R&D Program of China (2011BAE06B01), Shanghai Leading Academic Discipline Project Project No. B507, and the Fundamental Research Funds for the Central Universities and Special Fund for Agro-scientific Research in the Public Interest (201103007).

语种：英文

外文关键词：Amines; co-solvent; dehydrosulfurization; isothiocyanates; triphosgene

摘要：A mild and efficient method for the conversion of alkyl and aryl amines to isothiocyanates via dithiocarbamates has been developed using (CH3)(2)CO-CS2 as co-solvent and triphosgene as dehydrosulfurization reagent. High yields, mild reaction conditions and excellent functional group compatibility make it become a versatile synthetic method for the preparation of isothiocyanates compared with reported methods. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]