文献类型：期刊文献

英文题名：A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

作者：Wang, Rongchen[1,2];Chen, Jian[1,2];Gao, Jie[3];Chen, Ji-An[3];Xu, Ge[1,2];Zhu, Tianli[1,2];Gu, Xianfeng[3];Guo, Zhiqian[1,2];Zhu, Wei-Hong[1,2];Zhao, Chunchang[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China

年份：2019

卷号：10

期号：30

起止页码：7222

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20193207273923);WOS:【SCI-EXPANDED(收录号:WOS:000484202600007)】；

基金：We gratefully acknowledge the financial support by the National Natural Science Foundation of China (21874043 and 21672062), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

外文关键词：Enzymes - Dies - Medical imaging - Diseases - Optical properties - Fluorescence imaging - Infrared devices

摘要：The advance of cancer imaging requires innovations to establish novel fluorescent scaffolds that are excitable and emit in the near-infrared region with favorable Stokes shifts. Nevertheless, the lack of probes with these optimized optical properties presents a major bottleneck in targeted cancer imaging. By coupling of boron dipyrromethene platforms to enzymic substrates via a self-immolative benzyl thioether linker, we here report a strategy toward enzyme-activated fluorescent probes to satisfy these requirements. This strategy is applicable to generate various BODIPY-based probes across the NIR spectrum via introducing diverse electron-withdrawing substituents at the 3-position of the BODIPY core through a vinylene unit. As expected, such designed probes show advantages of two-channel ratiometric fluorescence and light-up NIR (I and II) emission with large Stokes shifts upon enzyme activation, enabling targeted cancer cell imaging and accurate tumor location by real-time monitoring of enzyme activities. This strategy is promising in engineering activatable molecular probes suitable for precision medicine.