文献类型：期刊文献

英文题名：In situ measurement of erythromycin crystal size distribution by focused beam reflective measurement technology

作者：Chen, Kui[1]; Cao, Bing[1]; Zhu, Jiawen[1]; Wu, Bin[1]; Ji, Lijun[1]

机构：[1] School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2009

卷号：4

期号：5

起止页码：832

外文期刊名：Asia-Pacific Journal of Chemical Engineering

收录：EI(收录号：20100212624267)

语种：英文

外文关键词：Particle size - Antibiotics - Grain size and shape - Particle size analysis - Size distribution

摘要：Many factors such as temperature, solvent and water-dosing rate have impact on erythromycin solventingout process. This article studies the water dosing effect on erythromycin solventing-out process measured by focused beam reflective measurement technology. Our experiments showed that the overall number of nucleated particles went through an explosive increasing after the metastable zone. Followed by a slight decreasing, it reached a relative constancy for a long time. This suggests that earlier crystal nucleation can be induced with higher water dosing rate, nevertheless, it is the same amount of water dosed when the overall crystal number reached its peak during the explosive emergence of crystals. After the overall particle number climaxed, further extension of crystal growth time would not bring any significant increase in crystal size. ? 2009 Curtin University of Technology and John Wiley & Sons, Ltd.