文献类型：期刊文献

英文题名：Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128

作者：Jiang, Lan[1];Huang, Pei[1,2];Ren, Biao[3];Song, Zhijun[4,5];Zhu, Guoliang[1];He, Wenni[6];Zhang, Jingyu[1];Oyeleye, Ayokunmi[7];Dai, Huanqin[8];Zhang, Lixin[1];Liu, Xueting[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Zunyi Med Univ, Dept Pediat Hematol Oncol, Affiliated Hosp, Guizhou Childrens Hosp, Zunyi 563000, Guizhou, Peoples R China;[3]Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China;[4]Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China;[5]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[6]Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China;[7]Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Cell & Mol Biol, Serdang 43400, Malaysia;[8]Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, Beijing 100101, Peoples R China

年份：2021

卷号：105

期号：12

起止页码：4975

外文期刊名：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

收录：;EI(收录号：20212610562640);WOS:【SCI-EXPANDED(收录号:WOS:000663488800002)】；

基金：We gratefully acknowledge the financial support from the National Key Research and Development Program of China (2020YFA090032 and 2019YFA0906200), the National Natural Science Foundation of China (21907031, 21877124, 82060675, 21977029, 31720103901, 21877038, 81903529), Guizhou Provincial Natural Science Foundation (QKHJC20201Y313), Doctoral Scientific Research Starting Foundation of Affiliated Hospital of Zunyi Medical University (YZ201809), Shanghai Rising-Star Program, the Open Project Funding of the State Key Laboratory of Bioreactor Engineering, the 111 Project (B18022), and Shanghai Science and Technology Commission (18JC1411900).

语种：英文

外文关键词：Marine-derived Actinomycete; Candida albicans; Polyene; Cyclic peptides

摘要：Marine microbes provide an important resource to discover new chemical compounds with biological activities beneficial to drug discovery. In our study, two new polyene macrolides, pyranpolyenolides A (1) and B (2), and one new natural cyclic peptide (9), together with two known polyenes (7 and 8) and three known cyclic peptides (10-12), were isolated from a culture of the marine Streptomyces sp. MS110128. In addition, four new polyene macrolides, pyranpolyenolides C-F (3-6), were identified as olefin geometric isomers that were most likely produced by photochemical conversion during the cultivation or isolation procedures. The pyranpolyenolides are 32-membered macrolides endowed with a conjugated tetraene and several pairs of 1,3-dihydroxyl groups. Pyranpolyenolides that contain a hydropyran group have not been previously reported. Four cyclic peptides (9-12) showed significant activities against Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant S. aureus with supporting MIC values ranging from 0.025 to 1.25 mu g/mL. These cyclic peptides containing piperazic moieties showed moderate activities with MIC values of 12.5 mu g/mL against Bacille Calmette Guerin (BCG), an attenuated form of the bovine. Additionally, cyclic peptide 12 showed moderate antifungal activity against Candida albicans with an MIC value of 12.5 mu g/mL.