文献类型：期刊文献

英文题名：Sustained-Release and Rapid-Release of Fenhexamid via the Two Different Photocages in a Light-Controllable Manner

作者：Yin, Qi[1];Li, Zongying[2];Shao, Zhongli[1];He, Zetao[1];Lv, Junjie[1];Shao, Xiaoguang[3];Shi, Lei[4];Fu, Wen[1,5];Shao, Xusheng[1,6,7,8]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Shandong Univ, Sch Pharmaceut Sci, Jinan 250000, Shandong, Peoples R China;[3]Agr Comprehens Serv Ctr Xiaqiu Town, Laizhou 261433, Shandong, Peoples R China;[4]Hangzhou Sinotek Qual & Technol Serv Co Ltd, Hangzhou 310052, Zhejiang, Peoples R China;[5]Guizhou Univ, Natl Key Lab Green Pesticide, Guiyang 550025, Guizhou, Peoples R China;[6]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[7]East China Univ Sci & Technol, Sch Pharm, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China;[8]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China

年份：2026

外文期刊名：ACS AGRICULTURAL SCIENCE & TECHNOLOGY

收录：WOS:【ESCI(收录号:WOS:001780409400001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (32472610, 32402439, and 32072441), the National Key Research and Development Program of China (2018YFD0200100), the Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00037), the Tobacco and Health funding program (2022539200340111), the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) and the project of National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University (SKL-GPL-KF-202405), Instrument Improvement Funds of Shandong University, (ts20250204), and the Shandong Provincial Natural Science Foundation (ZR2025QC1309).

语种：英文

外文关键词：release; controllable; photocage; pesticide efficacy; fenhexamid

摘要：Pesticides play a vital role in crop production and food security. Regarding the poor solubility, volatilization, and leaching of pesticides, few strategies can be employed to enhance pesticide efficacy on a spatiotemporal level. Herein, two different photocages derived from o-nitrobenzyl alcohol and coumarin were incorporated into fenhexamid (FEN) to generate novel molecules capable of providing controllable sustained-release and rapid-release of FEN, respectively. The 6-nitropiperanol (NP) modified FEN, NP-FEN, showed 153-fold differences in fungicidal activity between the light and dark treatments. In contrast, the 7-diethylamino-4-hydroxymethyl coumarin (COU) caged FEN, COU-FEN, showed a 13-fold increase in antifungal activity when exposed to light. Further physical and biological assays indicated that FEN could be effectively utilized in a light-controllable manner, which could be a future strategy to mitigate pesticide wasting and improve bioavailability in relation to pesticide residues, resistance, and environmental pollution.