文献类型：期刊文献

英文题名：Recent Advances in Stimuli-Responsive DNA-Based Hydrogels

作者：Wang, Chen[3];Zhang, Junji[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China

年份：2022

卷号：5

期号：5

起止页码：1934

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20220811699704);WOS:【ESCI(收录号:WOS:000813226100001)】；

基金：This work was supported by NSFC (21878086, 22122803) and the Shanghai Rising-Star Program (19QA1402500 to J.Z.).

语种：英文

外文关键词：DNA nanotechnology; pure DNA hydrogels; DNA-polymer hybrid hydrogels; stimuli responsiveness; adaptive functions

摘要：Stimuli-responsive DNA-based hydrogels are attracting growing interest because of their smart responsiveness, excellent biocompatibility, regulated biodegradability, and programmable design properties. Integration of reconfigurable DNA architectures and switchable supramolecular moieties (as cross-linkers) in hydrogels by responding to external stimuli provides an ideal approach for the reversible tuning structural and mechanical properties of the hydrogels, which can be exploited in the development of intelligent DNA-based materials. This review highlights recent advances in the design of responsive pure DNA hydrogels, DNA-polymer hybrid hydrogels, and autonomous DNA-based hydrogels with transient behaviors. A variety of chemically and physically triggered DNA-based stimuli-responsive hydrogels and their versatile applications in biosensing, biocatalysis, cell culture and separation, drug delivery, shape memory, self-healing, and robotic actuators are summarized. Finally, we address the key challenges that the field will face in the coming years, and future prospects are identified.